Effect of dietary restriction on lysosomal bodies and total protein synthesis in hepatocytes of aging rats.
Mech Ageing Dev
; 64(1-2): 49-59, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1630159
The accumulation of lysosomal bodies has long been considered to be an important correlate of aging. However it is not well established whether these age related changes interfere with cellular function. In this study, an evaluation of lysosomes by ultrastructural analysis was performed in livers of 4-6 and 20-24-month-old Sprague-Dawley female rats, fed ad libitum (A) or a restricted diet (R). An attempt was made to relate this parameter to hepatic protein synthesis, a liver function known to decrease with age and increase with dietary restriction. Aging was accompanied in both A and R animals with higher number and size of secondary lysosomes (lipofuscin) and by a decrease in total protein synthesis in hepatocytes. When compared to age matched ad libitum fed animals, livers of food restricted rats contained higher number of secondary lysosomes, yet exhibited higher protein synthetic capacity. Thus in hepatocytes, lipofuscin accumulation does not seem to interfere with cellular function.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Privação de Alimentos
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article