Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme.
Antimicrob Agents Chemother
; 49(12): 5123-6, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16304182
ABSTRACT
A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Tripanossomicidas
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Trypanosoma cruzi
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Doença de Chagas
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Espécies Reativas de Oxigênio
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Diterpenos
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NADPH Desidrogenase
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article