Mineralocorticoid-stimulating activity of adipose tissue.
Best Pract Res Clin Endocrinol Metab
; 19(4): 567-75, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16311217
ABSTRACT
Obesity is strongly associated with arterial hypertension. A positive correlation between obesity and plasma aldosterone levels has been observed by different investigators, suggesting that an abnormal secretion of aldosterone in obesity contributes to the development of arterial hypertension in obese subjects. The mechanisms proposed to explain this abnormal aldosterone production mainly involve the adipose renin-angiotensin system, an indirect effect of increased fatty acids, and direct adrenal stimulation by adipocyte secretory products. Indeed, adipose mineralocorticoid-stimulating activity was recently observed in isolated human adipocytes, suggesting a hitherto unknown direct involvement of adipose tissue in the regulation of blood pressure in obesity.
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Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
/
Mineralocorticoides
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article