Smoking and tuberculosis: the epidemiological association and immunopathogenesis.
Trans R Soc Trop Med Hyg
; 100(4): 291-8, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16325875
ABSTRACT
There is increasing evidence of a link between tuberculosis and smoking. This paper reviews the epidemiological evidence from the UK, China, India and the USA, summarizing some of the main papers which indicate an association. Where an association has been found there seems to be an increase in tuberculosis case rates of between two- and four-fold for those smoking in excess of 20 cigarettes a day, but it may be difficult to control for other factors, particularly alcohol consumption. The final part of the paper reviews possible mechanisms. A likely possibility is that nicotine turns off the production of TNF-alpha by the macrophages in the lungs, rendering the patient more susceptible to the development of progressive disease from latent Mycobacterium tuberculosis infection.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Fumar
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
America do norte
/
Asia
/
Europa
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article