[Potentiation of the acute toxic effects of cocaine by ethyl alcohol]. / Potentialisation des effets toxiques aigus de la cocaïne par l'alcool éthylique.

ABSTRACT

Ethyl alcohol increases significantly the lethality of cocaine intoxication in the rat. This lethality is not modified by nicardipine or flunarizine, antidotes to cocaine, and might be due to the formation of a newly identified active metabolite cocaethylene. In addition alcohol like cocaine inhibits the baro receptor reflex.