From A to Z and back? Multicompartment proteins in the sarcomere.
Trends Cell Biol
; 16(1): 11-8, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16337382
ABSTRACT
Sarcomeres, the smallest contractile units of striated muscle, are conventionally perceived as the most regular macromolecular assemblies in biology, with precisely assigned localizations for their constituent proteins. However, recent studies have revealed complex multiple locations for several sarcomere proteins within the sarcomere and other cellular compartments such as the nucleus. Several of these proteins appear to relocalize in response to mechanical stimuli. Here, we review the emerging role of these protein networks as dynamic information switchboards that communicate between the contractile machinery and the nucleus to central pathways controlling cell survival, protein breakdown, gene expression and extracellular signaling.
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Base de dados:
MEDLINE
Assunto principal:
Sarcômeros
/
Proteínas Musculares
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article