Social behavior deficits in the Fmr1 mutant mouse.
Behav Brain Res
; 168(1): 172-5, 2006 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-16343653
ABSTRACT
Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
/
Proteína do X Frágil da Deficiência Intelectual
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article