NG2: a component of the glial scar that inhibits axon growth.
J Anat
; 207(6): 717-25, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16367799
ABSTRACT
NG2 is a high-molecular-weight chondroitin sulphate proteoglycan found on the surfaces of oligodendrocyte precursor cells (OPCs). Here we review the history and biology of OPCs with an emphasis on their functions after experimentally induced CNS injury. Injury to brain or spinal cord results in the rapid accumulation of NG2-expressing OPCs in the glial scar that forms at the injury site. The glial scar is considered a biochemical and physical barrier to successful axon regeneration and the functional properties of NG2 suggest that it, along with other macromolecules, participates in the creation of this growth-inhibitory environment. NG2 is an important target for therapies designed to promote successful axon regrowth.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteoglicanas
/
Regeneração
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Células-Tronco
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Axônios
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Neuroglia
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Traumatismos do Sistema Nervoso
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Antígenos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article