Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells.
Curr Opin Genet Dev
; 2(2): 249-55, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1638119
ABSTRACT
Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Células-Tronco Hematopoéticas
/
Proteínas Oncogênicas de Retroviridae
/
Proteínas Proto-Oncogênicas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article