Long-term depression of kainate receptor-mediated synaptic transmission.
Neuron
; 49(1): 95-106, 2006 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-16387642
ABSTRACT
Kainate receptors (KARs) have been shown to be involved in hippocampal mossy fiber long-term potentiation (LTP); however, it is not known if KARs are involved in the induction or expression of long-term depression (LTD), the other major form of long-term synaptic plasticity. Here we describe LTD of KAR-mediated synaptic transmission (EPSC(KA) LTD) in perirhinal cortex layer II/III neurons that is distinct from LTD of AMPAR-mediated transmission, which also coexists at the same synapses. Induction of EPSC(KA) LTD requires a rise in postsynaptic Ca(2+) but is independent of NMDARs or T-type voltage-gated Ca(2+) channels; however, it requires synaptic activation of inwardly rectifying KARs and release of Ca(2+) from stores. The synaptic KARs are regulated by tonically activated mGluR5, and expression of EPSC(KA) LTD occurs via a mechanism involving mGluR5, PKC, and PICK1 PDZ domain interactions. Thus, we describe the induction and expression mechanism of a form of synaptic plasticity, EPSC(KA) LTD.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Ácido Caínico
/
Transmissão Sináptica
/
Córtex Entorrinal
/
Depressão Sináptica de Longo Prazo
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article