Immunohistochemical characterization of cellular infiltrates in epidermal tumors induced by two-stage and complete chemical carcinogenesis in mouse skin.
J Dermatol
; 19(3): 146-52, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1640020
ABSTRACT
We investigated the population and pattern of the infiltrated cells in both benign and malignant epidermal tumors which were induced chemically with benzo(a)pyrene (B(a)P) in murine skin. In benign papillomas, which were evolved by a two stage carcinogenesis regimen, a slight to mild inflammatory infiltration around the tumors was observed, and cells infiltrating into the tumor nests were rarely seen. In carcinomas, which were produced by a complete carcinogenesis regimen, a dense inflammatory infiltration was observed around the tumor nests. The infiltrated cells were characterized as T-lymphocytes, macrophages, and neutrophils. Natural killer (NK) cells were found around and in the tumor nests, but their number was small. Both T-lymphocytes and macrophages were found to invade the tumor nests in squamous cell carcinoma whose duration was more than four weeks. This experimental carcinogenesis animal model allows the detailed quantitative and functional analysis of the infiltration of immunocompetent cells into epidermal tumors.
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Base de dados:
MEDLINE
Assunto principal:
Papiloma
/
Neoplasias Cutâneas
/
Carcinoma de Células Escamosas
/
Linfócitos do Interstício Tumoral
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article