Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.
Eur J Pharmacol
; 531(1-3): 259-63, 2006 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-16410000
ABSTRACT
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT1 and AT2 receptor blockers candesartan and PD 123319. Both angiotensin AT1 and AT2 receptors were detected on the endothelium by immunohistochemistry.
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Base de dados:
MEDLINE
Assunto principal:
Vasoconstrição
/
Angiotensina II
/
Fatores Biológicos
/
Artérias Cerebrais
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article