Changes in lipid metabolism in chronic hepatitis C.
World J Gastroenterol
; 11(41): 6422-8, 2005 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-16425410
ABSTRACT
AIM:
To investigate the relationship between certain biochemical parameters of lipid metabolism in the serum and steatosis in the liver.METHODS:
The grade of steatosis (0-3) and histological activity index (HAI, 0-18) in liver biopsy specimens were correlated with serum alanine aminotransferase (ALT), total cholesterol and triglyceride levels in 142 patients with chronic hepatitis C (CH-C), and 28 patients with non-alcoholic fatty liver disease (NAFLD) without hepatitis C virus (HCV) infection. The serum parameters were further correlated with 1,797 age and sex matched control patients without any liver diseases.RESULTS:
Steatosis was detected in 90 out of 142 specimens (63%) with CH-C. The ALT levels correlated with the grade of steatosis, both in patients with CH-C and NAFLD (P<0.01). Inserting the score values of steatosis as part of the HAI, correlation with the ALT level (P<0.00001) was found. The triglyceride and cholesterol levels were significantly lower in patients with CH-C (with and without steatosis), compared to the NAFLD group and to the virus-free control groups.CONCLUSION:
Our study confirms the importance of liver steatosis in CH-C which correlates with lower lipid levels in the sera. Inclusion of the score of steatosis into HAI, in case of CH-C might reflect the alterations in the liver tissue more precisely, while correlating with the ALT enzyme elevation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hepatite C Crônica
/
Metabolismo dos Lipídeos
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Fígado Gorduroso
Limite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article