[Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib].
Rinsho Ketsueki
; 46(11): 1226-8, 2005 Nov.
Article
em Ja
| MEDLINE
| ID: mdl-16440809
ABSTRACT
A 57-year-old woman with chronic myeloid leukemia showing severe basophilia (WBC 17.1 X 10(9)/L, basophils 23%) was treated with 400mg imatinib in June 2003. A high basophil count (WBC 10.6 X 10(9)/L, basophils 31%) was still observed after 1 week of therapy. After 9 days of therapy, she developed generalized pruritic skin erythema, chills and high fever. After terminating imatinib treatment, prednisolone therapy was initiated. The rash quickly disappeared. Four days after withdrawal of imatinib, leukocyte count was 13.0 X 10(9)/L with 3% of basophils, suggesting the possibility that rapid decrease in basophils following imatinib therapy may induce severe cutaneous reactions.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Pirimidinas
/
Basófilos
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Eritema
/
Leucopenia
/
Antineoplásicos
Limite:
Female
/
Humans
/
Middle aged
Idioma:
Ja
Ano de publicação:
2005
Tipo de documento:
Article