Thyroid hormone action at the cellular, genomic and target gene levels.
Mol Cell Endocrinol
; 246(1-2): 121-7, 2006 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-16442701
ABSTRACT
Thyroid hormone (TH) plays important roles in metabolism, growth and differentiation. Thyroid hormone receptors (TRs) are ligand-regulatable transcription factors that bind both TH and DNA enhancer sequences in the promoter region of target genes where they can interact with co-repressor and co-activator complexes. These interactons, in turn, have consequent effects on transcription. This review describes studies on TH action from our laboratory examining the cellular localization and motility of TRs using green fluorescent fusion proteins, gene expression profiles of TH in WT and TRalpha and TRbeta KO mice, as well as general transcription factor and co-activator recruitment on the promoters of target genes by TH in chromatin immunoprecipitation assays.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios Tireóideos
/
Receptores dos Hormônios Tireóideos
/
Regiões Promotoras Genéticas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article