Identification and immunotherapeutic targeting of antigens induced by chemotherapy.
Nat Biotechnol
; 24(2): 205-9, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16444269
ABSTRACT
Cancer cells differ from normal cells in their response to chemotherapy. We exploited this dissimilarity by identifying and targeting tumor-specific, cell-surface proteins whose expression is induced by the chemotherapeutic irinotecan (CPT-11; Camptosar). A cytotoxin-armed antibody reactive with one of these drug-induced surface proteins, the LY6D/E48 antigen, originally identified as the target of a monoclonal antibody reactive with squamous cell carcinomas, caused complete regression of colorectal tumor xenografts in mice treated with CPT-11, whereas either agent alone was less effective. These results suggest that a positive therapeutic index may be generated for other drug combinations by immunotherapeutic targeting of chemotherapy-induced antigens.
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Base de dados:
MEDLINE
Assunto principal:
Camptotecina
/
Carcinoma de Células Escamosas
/
Sistemas de Liberação de Medicamentos
/
Imunoterapia
/
Anticorpos Monoclonais
/
Antígenos de Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article