Antimicrobial resistance in E.coli associated with urinary tract infection in the west of Ireland.
Ir J Med Sci
; 174(4): 6-9, 2005.
Article
em En
| MEDLINE
| ID: mdl-16445153
ABSTRACT
BACKGROUND:
Knowledge of antimicrobial resistance patterns in E. coli, the predominant pathogen associated with urinary tract infection (UTI) is important as a guide in selecting empirical antimicrobial therapyAIMS:
To describe the antimicrobial susceptibility of E. coli associated with UTI in a region in the West of Ireland.METHODS:
A collection of 934 E. coli isolates associated with UTI were tested for susceptibility to a panel of antimicrobial agents by the disc diffusion method of the National Committee for Clinical Laboratory Standards.RESULTS:
More than 50% of E. coli were resistant to ampicillin, more than 40% resistant to sulphonamide and more than 30% resistant to trimethoprim. From 7.9% (community) to 12.5% (hospital) are resistant to co-amoxiclav with approximately 20% of isolates of intermediate susceptibility. In general practice most E. coli remain susceptible to nitrofurantoin (96.7%), nalidixic acid (93.9%) and ciprofloxacin (94.7%). For all agents rates of resistance were higher in hospital as compared with general practice isolates. Three isolates with the phenotype of Extended Spectrum Beta-lactamase (ESBL) resistance were detected.CONCLUSIONS:
Ampicillin/amoxicillin are not suitable for empiric therapy of UTI in general practice or hospital patients in this region. There is doubt as to the role of trimethorpim or co-trimoxazole for empiric therapy of UTI. Nitrofurantoin, nalidixic acid and ciprofloxacin are active against the great majority of UTI associated E. coli.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
/
Farmacorresistência Bacteriana
/
Escherichia coli
/
Anti-Infecciosos Urinários
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article