Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease.
Eur J Pharmacol
; 533(1-3): 215-21, 2006 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-16455073
ABSTRACT
Kinins are proinflammatory peptides that mediate a variety of pathophysiological responses. These actions occur through stimulation of two pharmacologically distinct receptor subtypes B1 and B2. In both human and animal airways, the majority of kinin-induced effects including bronchoconstriction, increases in vascular permeability and mucus secretion and cholinergic and sensory nerve stimulation appear to be bradykinin B2-receptor mediated. Peptidic and non-peptidic receptor antagonists have been developed as potential therapeutic agents. These antagonists are effective in blocking kinin-induced effects in a variety of animal models and in some instances, have been used effectively in animal models of allergic airway disease to alleviate allergen-induced pathophysiological airway responses. This review summarizes relevant studies supporting the evidence that bradykinin B2 receptor antagonism and/or upstream inhibition of tissue kallikrein will be beneficial in the treatment of inflammatory airway diseases.
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Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Bradicinina
/
Anti-Inflamatórios não Esteroides
/
Antagonistas de Receptor B2 da Bradicinina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article