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Botulinum toxin: a novel therapeutic option for bronchial asthma?
Lim, Erle C H; Ong, Benjamin K C; Oh, Vernon M S; Seet, Raymond C S.
Afiliação
  • Lim EC; Yong Loo Lin School of Medicine, National University of Singapore, Division of Neurology, National University Hospital, Singapore. mdcelch@nus.edu.sg
Med Hypotheses ; 66(5): 915-9, 2006.
Article em En | MEDLINE | ID: mdl-16455206
Two components are essential for the development of an attack of bronchial asthma: inflammation and bronchoconstriction, the latter being mediated by smooth muscle contraction. Despite the efficacy of chronic therapy, many asthmatics relapse. Measures to inhibit contraction of the airway smooth muscle, such as vagotomy and thermoablation, may decrease the bronchoconstrictor component of the asthma attack and help to decrease morbidity and mortality from the disease. Botulinum toxin acts to weaken skeletal and smooth muscle by preventing the docking of the acetylcholine vesicle on the inner surface of the presynaptic membrane, thus causing chemical denervation and paresis of skeletal or smooth muscle. We explore the possibility that administration of botulinum toxin may achieve the same effect in bronchial asthma and examine the evidence to support this hypothesis.
Assuntos
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Base de dados: MEDLINE Assunto principal: Asma / Toxinas Botulínicas / Modelos Biológicos / Músculo Liso Vascular Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Asma / Toxinas Botulínicas / Modelos Biológicos / Músculo Liso Vascular Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article