Discovery of novel heterocyclic factor VIIa inhibitors.
Bioorg Med Chem Lett
; 16(8): 2270-3, 2006 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-16460932
ABSTRACT
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
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Base de dados:
MEDLINE
Assunto principal:
Tromboplastina
/
Fator VIIa
/
Fibrinolíticos
/
Aminopiridinas
/
Compostos Heterocíclicos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article