[Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors].
Zhonghua Bing Li Xue Za Zhi
; 34(9): 566-8, 2005 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-16468306
ABSTRACT
OBJECTIVE:
To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).METHODS:
The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.RESULTS:
The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.CONCLUSIONS:
DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Córtex Cerebral
/
Tumores Neuroectodérmicos Primitivos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
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Child, preschool
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article