Neuropeptide alpha-MSH antagonizes IL-6- and TNF-induced fever.
Peptides
; 12(2): 297-9, 1991.
Article
em En
| MEDLINE
| ID: mdl-1648713
ABSTRACT
The pro-opiomelanocortin-derived peptide melanocyte stimulating hormone (alpha-MSH) antagonizes the fever induced by several stimuli including endotoxin, endogenous pyrogen, and certain cytokines. To determine if alpha-MSH can antagonize the pyrogenic action of recombinant IL-6 and TNF directly within the central nervous system, the cytokines were injected with and without alpha-MSH (200 ng) into a lateral cerebral ventricle of rabbits and rectal temperature was monitored continuously. Central administration of both cytokines caused fever. However, when alpha-MSH was injected after cytokine administration, the fevers were markedly reduced. The results are consistent with previous observations on the antipyretic effect of alpha-MSH and they show that the peptide can act within the brain to antagonize pyrogenic actions of specific cytokines believed to be important in CNS mediation of fever.
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Base de dados:
MEDLINE
Assunto principal:
Alfa-MSH
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Febre
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article