Infection with human herpesvirus type 8 and Kaposi's sarcoma in Sardinia.
Infection
; 34(1): 39-42, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16501902
ABSTRACT
BACKGROUND:
A cross-sectional study was conducted in the provinces of Sassari (northern Sardinia, covered by a population-based cancer registry), and of Cagliari (southern Sardinia) to estimate the prevalence of infection with human herpesvirus type 8 (HHV8) and the incidence of classic Kaposi's sarcoma (KS) among HHV8-infected individuals. PATIENTS ANDMETHODS:
Sera from 297 hospitalized persons potentially at risk of developing classic KS (i. e., those aged 50 years or older) were tested for antibodies against HHV8. HHV8 seroprevalence rates (with 95% confidence intervals-CI) and yearly incidence rates (IR/100,000) of KS were calculated according to age and sex.RESULTS:
Of tested individuals, 32.0% had antibodies against HHV8 in Sassari and 30.0% in Cagliari. Estimated IR of KS among HHV8-positive persons and KSHHV8 ratio were two times higher in Sassari (13,891) than in Cagliari (18,114), and higher in men (12,846 in Sassari; 15,483 in Cagliari) as compared to women (16,827 in Sassari; 112,489 in Cagliari).CONCLUSIONS:
Although the overall prevalence of HHV8 seemed similar in Sassari and in Cagliari, the risk of KS was higher in Sassari, suggesting that different cofactor(s), or different distribution of the same cofactor(s) between the two provinces of Sardinia, might have played a role in KS development.
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Kaposi
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Infecções por Herpesviridae
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Herpesvirus Humano 8
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Anticorpos Antivirais
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article