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Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells.
Worbs, Tim; Bode, Ulrike; Yan, Sheng; Hoffmann, Matthias W; Hintzen, Gabriele; Bernhardt, Günter; Förster, Reinhold; Pabst, Oliver.
Afiliação
  • Worbs T; Institute of Immunology, Department of Visceral and Transplantation Surgery, Hannover Medical School, 30625 Hannover, Germany.
J Exp Med ; 203(3): 519-27, 2006 Mar 20.
Article em En | MEDLINE | ID: mdl-16533884
Oral tolerance induction is a key feature of intestinal immunity, generating systemic nonresponsiveness to ingested antigens. In this study, we report that orally applied soluble antigens are exclusively recognized in the intestinal immune system, particularly in the mesenteric lymph nodes. Consequently, the initiation of oral tolerance is impeded by mesenteric lymphadenectomy. Small bowel transplantation reveals that mesenteric lymph nodes require afferent lymph to accomplish the recognition of orally applied antigens. Finally, oral tolerance cannot be induced in CCR7-deficient mice that display impaired migration of dendritic cells from the intestine to the mesenteric lymph nodes, suggesting that immunologically relevant antigen is transported in a cell-bound fashion. These results demonstrate that antigen transport via afferent lymphatics into the draining mesenteric lymph nodes is obligatory for oral tolerance induction, inspiring new therapeutic strategies to exploit oral tolerance induction for the prevention and treatment of autoimmune diseases.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Movimento Celular / Imunidade nas Mucosas / Receptores de Quimiocinas / Tolerância Imunológica / Antígenos Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Movimento Celular / Imunidade nas Mucosas / Receptores de Quimiocinas / Tolerância Imunológica / Antígenos Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article