Mouse models of inflammatory bowel disease.
Curr Opin Drug Discov Devel
; 9(2): 207-17, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16566291
ABSTRACT
The past decade has seen an abundance of new mouse models that mimic the human inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis. These mouse models of IBD have provided great insight into the potential mechanisms that drive homeostatic dysregulation in the intestine, which manifests as mucosal inflammation. Within this review, the different animal models that have been employed to gain a greater understanding of the pathogenesis of IBD are discussed and some of the new biological drugs that have emerged as potential therapeutics as a result of these mouse modeling studies are reviewed.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article