NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation.
Nucleic Acids Res
; 34(6): 1847-53, 2006.
Article
em En
| MEDLINE
| ID: mdl-16595798
ABSTRACT
The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for bacterial trans-translation, a ribosomal rescue mechanism. We report the solution structure of PK1 from Aquifex aeolicus, which despite an unprecedented small number of nucleotides and thus an unprecented compact size, displays a very high thermal stability. Several unusual structural features account for these properties and indicate that PK1 belongs to the class of ribosomal frameshift pseudoknots. This suggests a similarity between the mechanism of programmed ribosomal frameshifting and trans-translation.
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Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
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RNA Bacteriano
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RNA Mensageiro
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RNA de Transferência
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Modelos Moleculares
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article