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Adhesion of Borrelia garinii to neuronal cells is mediated by the interaction of OspA with proteoglycans.
Rupprecht, Tobias A; Koedel, Uwe; Heimerl, Christiane; Fingerle, Volker; Paul, Robert; Wilske, Bettina; Pfister, Hans-Walter.
Afiliação
  • Rupprecht TA; Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, D-81377 Munich, Germany.
J Neuroimmunol ; 175(1-2): 5-11, 2006 Jun.
Article em En | MEDLINE | ID: mdl-16603253
To study pathogenic mechanisms of Lyme meningoradiculitis, dorsal root ganglia (DRG) cells and two neuronal cell lines (B50, SH-SY5Y) were incubated with Borrelia garinii, the Borrelia species most frequently isolated from CSF of Lyme neuroborreliosis patients in Europe. We demonstrated that (I) OspA-positive B. garinii adhere to neuronal cells, (II) Borrelia adhesion can be blocked by a monoclonal antibody against OspA, (III) preincubation with proteoglycans interferes with the adhesion process and (IV) rOspA directly binds to the proteoglycans. This indicates that both OspA and the cell bound proteoglycans are involved in the attachment of B. garinii to neuronal cells.
Assuntos
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Base de dados: MEDLINE Assunto principal: Proteoglicanas / Proteínas da Membrana Bacteriana Externa / Aderência Bacteriana / Grupo Borrelia Burgdorferi / Moléculas de Adesão Celular / Lipoproteínas / Antígenos de Superfície / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Proteoglicanas / Proteínas da Membrana Bacteriana Externa / Aderência Bacteriana / Grupo Borrelia Burgdorferi / Moléculas de Adesão Celular / Lipoproteínas / Antígenos de Superfície / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article