Homeostatic regulation of glutamate release in response to depolarization.
Mol Neurobiol
; 33(2): 133-53, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16603793
ABSTRACT
Proper nervous system function requires a balance between excitation and inhibition. Systems of homeostasis may have evolved in neurons to help maintain or restore balance between excitation and inhibition, presumably because excessive excitation can cause dysfunction and cell death. This article reviews evidence for homeostatic mechanisms within the hippocampus that lead to differential regulation of glutamate and gamma-aminobutyric acid release in response to conditions of excess depolarization. We recently found differential effects on glutamate release at the level of action potential coupling to transmitter release, vesicular release probability, and vesicle availability. Such differential regulation may help to prevent excitotoxicity and runaway excitation.
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Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Terminações Pré-Sinápticas
/
Transmissão Sináptica
/
Ácido Glutâmico
/
Hipocampo
/
Homeostase
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article