Ras ubiquitination: coupling spatial sorting and signal transmission.
Cancer Cell
; 9(4): 243-4, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16616329
ABSTRACT
H-Ras, N-Ras, and K-Ras proteins have distinct biological properties, despite ubiquitous expression and similar affinities for regulators and effectors. C-terminal hypervariable regions that distinguish H-Ras, N-Ras, and K-Ras proteins direct them to distinct membrane compartments, where they may encounter regulators and effectors at different local concentrations. Jura and coworkers now report that these membrane-targeting domains direct differential ubiquitination of Ras proteins and so provide a molecular mechanism to explain the sorting process and, perhaps, some of the dramatic differences in biological potency among H-Ras, N-Ras, and K-Ras proteins.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas ras
/
Ubiquitina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article