Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism.
Biol Psychiatry
; 60(2): 186-91, 2006 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-16616719
ABSTRACT
BACKGROUND:
The serotonin transporter (5-HTT) has long been considered likely to play a role in autism. Hyperserotonemia has been consistently found in a proportion of autistic patients, and the use of selective serotonin reuptake inhibitors (SSRIs) can have a positive effect in treating some symptoms of autism. Specific variants of the 5-HTT gene, SLC6A4, especially the insertion-deletion 5-HTTLPR promoter locus, have been found to modulate its expression and transporter function.METHODS:
We examined the transmission of the short or long allele of 5-HTTLPR locus to affected individuals, using a large cohort of 352 families. In addition, we screened five single nucleotide polymorphisms (SNPs) in the 5' region of SLC6A4 previously reported to be positively associated with autism, as well as 4 additional SNPs also in the 5' region.RESULTS:
No association of the 5-HTTLPR locus with autism was found. Furthermore, no evidence for association of any of the nine SNPs covering the SLC6A4 gene, or any of their haplotypes, was observed in our study. Using obsessive-compulsive behaviors (OCB), severe OCBs or rigid-compulsive subsets of our cohort gave the same negative results.CONCLUSIONS:
SLC6A4 variants do not appear to be significantly involved in the liability to autism.
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Autístico
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article