Microwave-assisted organic synthesis of 3-(D-Gluco-pentitol-1-yl)-1H-1,2,4-triazole.
Nucleosides Nucleotides Nucleic Acids
; 25(3): 325-35, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16629125
ABSTRACT
The condensation of D-glucono- and D-galactono-1,5-lactone and thiocarbohydrazide to give 3-(D-alditol-1-yl)-4-amino-5-mercapto-1,2,4-triazoles 4 and 5 is accelerated by the use of microwave-assisted organic reaction (MAOS). The deamination and dethiolation of compound 4 to give 6 was also accelerated by the use of MAOS. Condensation of 4 and 5 with p-nitrobenzaldehyde afforded Schiff bases 8 and 9, respectively, within 4 min under microwave irradiation (MWI), whereas with ethyl chloroacetate the thioalkylated products 14 and 15 were obtained in 8 min. The structures of the synthesized compounds were confirmed by 1H NMR, 2D NMR, and mass spectra.
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Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Micro-Ondas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article