Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.
Bioorg Med Chem Lett
; 16(13): 3434-9, 2006 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-16644215
ABSTRACT
Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P(2) binding pocket of human mast cell tryptase, while building in a high degree of selectivity over human trypsin and other serine proteases.
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Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Serina Endopeptidases
/
Inibidores Enzimáticos
/
Mastócitos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article