Synthesis and inhibitory activity of 8-substituted 2-deoxy-beta-KDO against CMP-KDO synthetase.
Nat Prod Res
; 20(4): 361-70, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16644531
ABSTRACT
3-Deoxy-D-manno-octulosonate cytidyltransferase (CMP-KDO synthetase) is involved in the biosynthesis of lipopolysaccharide (LPS) which is an essential component of the outer membrane of gram-negative bacteria. New CMP-KDO synthetase inhibitors, 8-substituted derivatives of 2-deoxy-beta-KDO (2) have been prepared. Compounds 8, 11, 15 and 16 in which the 8-hydroxyl group of 2 is replaced by guanidine, di(carbamoylethyl)amino, p-methoxy- or p-nitro-benzyloxycarbonylamino, respectively affect moderately the CMP-KDO synthetase activity.
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Base de dados:
MEDLINE
Assunto principal:
Dissacarídeos
/
Nucleotidiltransferases
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article