Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor.
Brain Res
; 562(1): 149-53, 1991 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-1666014
ABSTRACT
192 IgG, a monoclonal antibody to the rat nerve growth factor (NGF) receptor, was disulfide-coupled to saporin, a ribosome-inactivating protein. Systemic injection of 192 IgG-saporin destroyed sympathetic postganglionic neurons and some sensory neurons. Injection of 192 IgG-saporin into the lateral ventricle destroyed cholinergic neurons of the basal forebrain. These results show that antineuronal immunotoxins are a powerful approach that may prove useful in a variety of neurobiological applications.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Imunotoxinas
/
Receptores de Superfície Celular
/
Gânglios Simpáticos
/
Neurônios
/
N-Glicosil Hidrolases
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article