Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
J Clin Microbiol
; 44(5): 1847-50, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16672419
ABSTRACT
We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-10
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Infecções por Citomegalovirus
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Quimiocina CCL2
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Receptores CCR5
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Polimorfismo de Nucleotídeo Único
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Transplante de Células-Tronco
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article