[The effects of rapid and slow infusion of fluid on coagulation factors in hemorrhagic shock: an experimental dogs model]. / Hemorajik sokta hizli ve yavas sivi infüzyonunun koagülasyon faktörleri üzerine etkisi: köpekte deneysel çalisma.
Ulus Travma Acil Cerrahi Derg
; 12(2): 95-100, 2006 Apr.
Article
em Tr
| MEDLINE
| ID: mdl-16676247
ABSTRACT
BACKGROUND:
The diagnosis of hemorrhagic shock in a patient with tachycardia and hypotension is generally straightforward. The difficulty lies in the selection of optimal approach for the patient. In this study on a canine model of deep hemorrhagic shock induced by bleeding, we used various amounts of fluid infusion to determine the most appropriate amount of fluid resuscitation.METHODS:
The study included 30 mongrel dogs. Mongrel dogs were randomized to three equal groups of 10. The control group received no treatment. The rapid infusion group received 60 mL/kg of lactated Ringer's solution in half an hour whereas the third group received 30 mL/kg during the same time period.RESULTS:
The lactate decreased in the two treatment groups. The platelet and fibrinogen levels did not vary in the slow infusion group but decreased markedly in the rapid infusion group.CONCLUSION:
In conclusion, fluid resuscitation should not be unnecessarily aggressive. The coagulation parameters are diluted in proportion with the amount of fluid given. Blood lactate level can be used as a guiding marker in evaluation of treatment effectiveness of hemorrhagic shock patients.
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Base de dados:
MEDLINE
Assunto principal:
Choque Hemorrágico
/
Hidratação
/
Soluções Isotônicas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Tr
Ano de publicação:
2006
Tipo de documento:
Article