[Study on hepatitis C virus genotyping in Yixing area, Jiangsu province].
Zhonghua Liu Xing Bing Xue Za Zhi
; 26(11): 901-3, 2005 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-16676614
ABSTRACT
OBJECTIVE:
To investigate the distribution of hepatitis C virus (HCV) genotypes in Yixing, Jiangsu province.METHODS:
Genotypes identification on sera samples were obtained from 158 donors who had already been anti-HCV positive through PCR method with type specific primer designed according to the sequence of 5'non-coding region (5'NCR). 5'NCR was also sequenced and compared with published date. Genotypes distribution was investigated in patients with different sex and clinical types of hepatitis C.RESULTS:
Of the total 158 patients, 95 were HCV RNA positive in which 80 patients having genotype 1b (80/95; 84.4%), 5 patients having genotype 2(5/95; 5.3%), 5 patients with 1b/2 mixed genotypes (5/ 95; 5.3%) and another 5 patients whose genotype undetermined. The difference on the distribution of HCV genotypes was significant between female and male patients (P < 0.05) but not in different kinds of hepatitis C patients.CONCLUSION:
Type 1b was the predominant HCV genotype in Yixing area.
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Base de dados:
MEDLINE
Assunto principal:
Hepatite C
/
Hepacivirus
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article