Attenuated spread of X-inactivation in an X;autosome translocation.
Proc Natl Acad Sci U S A
; 103(20): 7706-11, 2006 May 16.
Article
em En
| MEDLINE
| ID: mdl-16679409
ABSTRACT
X inactivation in female mammals involves transcriptional silencing of an entire chromosome in response to a cis-acting noncoding RNA, the X inactive-specific transcript (Xist). Xist can also inactivate autosomal sequences, for example, in X;autosome translocations; but here, silencing appears to be relatively inefficient. This variation has been attributed to either attenuated spreading of Xist RNA at the onset of X inactivation or inefficient maintenance of autosomal silencing. Evidence to date has favored the latter. Here, we demonstrate attenuated spreading of Xist RNA at the onset of X inactivation in the T(X;4)37H X;autosome translocation. Our findings provide direct evidence that underlying chromosome/chromatin features can disrupt spreading of the primary inactivating signal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Cromossomo X
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RNA não Traduzido
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Cromossomos de Mamíferos
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Inativação do Cromossomo X
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article