Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
Bioorg Med Chem Lett
; 16(14): 3713-8, 2006 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-16697190
ABSTRACT
We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Lipoxinas
/
Receptores de Formil Peptídeo
/
Inflamação
/
Anti-Inflamatórios
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article