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Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice.
Ardayfio, Paul; Kim, Kwang-Soo.
Afiliação
  • Ardayfio P; Laboratory of Molecular Neurobiology, Mclean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Behav Neurosci ; 120(2): 249-56, 2006 Apr.
Article em En | MEDLINE | ID: mdl-16719689
Chronic hypercortisolemia is a hallmark of neuroendocrine and psychiatric disorders, such as Cushing's disease and depression. Whether cortisol directly contributes to the altered mood and anxiety symptoms seen in these diseases remains unclear. To address this, the authors have modeled hypercortisolemia by administering corticosterone in the drinking water of female Swiss Webster mice for 17 or 18 days (13 mg/kg). Light-dark emergence, startle habituation, and startle reactivity were measured. Chronic but not acute treatment with corticosterone increased the latency to emerge into the light compartment, an anxiogenic-like effect. Chronic corticosterone treatment did not affect startle habituation, but did reduce startle reactivity. This study suggests that chronic hypercortisolemia may contribute to anxiety-related behavior in patients with Cushing's disease and depression.
Assuntos
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Base de dados: MEDLINE Assunto principal: Ansiedade / Corticosterona / Hiperfunção Adrenocortical / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Ansiedade / Corticosterona / Hiperfunção Adrenocortical / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2006 Tipo de documento: Article