Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 16(15): 3906-12, 2006 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-16730983
ABSTRACT
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported.
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Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Pirrolidinonas
/
Antagonistas da Serotonina
/
Antagonistas do Receptor 5-HT2 de Serotonina
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article