7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Bioorg Med Chem Lett
; 16(15): 3993-7, 2006 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-16735116
ABSTRACT
New 4-phenylamino-3-quinolinecarbonitriles with a 7-ethynyl group substituted by a pyridine, phenyl or thiophene ring containing basic water solubilizing groups were prepared and evaluated as Src kinase inhibitors. Of these new analogs, potent activity was observed with compounds having a (2,4-dichloro-5-methoxyphenyl)amino group at C-4, a methoxy or ethoxy group at C-6, and a pyridyl group bearing a dimethylamine or N-methylpiperazine on the ethynyl group at C-7.
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Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Água
/
Quinases da Família src
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article