The human muscle proteome in aging.
J Proteome Res
; 5(6): 1344-53, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16739986
ABSTRACT
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Músculo Esquelético
/
Proteoma
Limite:
Adult
/
Aged
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article