The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.
J Exp Med
; 203(6): 1543-50, 2006 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-16754716
ABSTRACT
It is well established that the pre-T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRbeta rearrangements. However, Ptcra- as well as Tcra-targeting experiments have suggested that the early expression of Tcra in CD4- CD8- cells can partially rescue the development of alphabeta CD4+ CD8+ cells in Ptcra-deficient mice. In this study, we show that the TCR E delta but not E alpha enhancer function is required for the cell surface expression of alphabetaTCR on immature CD4- CD8- T cell precursors, which play a crucial role in promoting alphabeta T cell development in the absence of pre-TCR. Thus, alphabetaTCR expression by CD4- CD8- thymocytes not only represents a transgenic artifact but occurs under physiological conditions.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Rearranjo Gênico do Linfócito T
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Linfócitos T CD4-Positivos
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Receptores de Antígenos de Linfócitos T alfa-beta
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article