Signaling by the arc two-component system provides a link between the redox state of the quinone pool and gene expression.
Antioxid Redox Signal
; 8(5-6): 781-95, 2006.
Article
em En
| MEDLINE
| ID: mdl-16771670
ABSTRACT
The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic growth conditions, ArcB autophosphorylates and transphosphorylates ArcA, which in turn represses or activates the expression of its target operons. Under aerobic conditions, ArcB acts as a phosphatase that catalyzes the dephosphorylation of ArcA-P and thereby releasing its transcriptional regulation. The events for Arc signaling, including signal reception and kinase regulation, signal transmission, amplification, as well as signal output and decay are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Quinonas
/
Proteínas Repressoras
/
Bactérias
/
Proteínas da Membrana Bacteriana Externa
/
Transdução de Sinais
/
Regulação da Expressão Gênica
/
Proteínas de Escherichia coli
/
Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article