CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.
Immunology
; 118(2): 250-6, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16771860
ABSTRACT
CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll-like receptor (TLR)3 and TLR9. Nuclear factor-kappaB activation, an important downstream consequence of TLR3 and TLR9 signalling, is also increased in CD45-/- BMDC. BMDC of CD45-/- mice also produce more TNF and IL-6 following stimulation with the cytokines TNF and interferon-alpha. These results show that TLR signalling is increased in CD45-/- dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Antígenos Comuns de Leucócito
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article