Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors.
Leuk Res
; 30(11): 1385-90, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-16780947
ABSTRACT
A novel lymphoma cell line, designated TMD8 was established from cells of a patient with diffuse large B-cell lymphoma. TMD8 cells expressed HES1 mRNA, suggesting constitutive activation of Notch signaling. TMD8 cells expressed normal-sized Notch1 protein, and showed no mutations in the NOTCH1 gene. Cell growth was suppressed by gamma-secretase inhibitors (GSI). It was reported that GSI suppressed growth of T-cell acute lymphoblastic leukemia (T-ALL) cell lines, which frequently had NOTCH1 mutations. In addition to T-ALL, TMD8 is another unique cell line sensitive to GSI, and is useful to study effects of GSI in molecular targeting therapy.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Linfoma de Células B
/
Linhagem Celular Tumoral
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Proliferação de Células
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Dipeptídeos
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Inibidores Enzimáticos
/
Secretases da Proteína Precursora do Amiloide
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article