Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis.

Klont, Rocus R; Mennink-Kersten, Monique A S H; Ruegebrink, Dorien; Rijs, Antonius J M M; Blijlevens, Nicole M A; Donnelly, J Peter; Verweij, Paul E

Klont, Rocus R; Mennink-Kersten, Monique A S H; Ruegebrink, Dorien; Rijs, Antonius J M M; Blijlevens, Nicole M A; Donnelly, J Peter; Verweij, Paul E.

Afiliação

Klont RR; Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. r.klont@mmb.umcn.nl

Clin Infect Dis ; 43(3): e23-5, 2006 Aug 01.

Article em En | MEDLINE | ID: mdl-16804836

ABSTRACT

ABSTRACT

A paradoxical increase in circulating Aspergillus antigen was observed during treatment with caspofungin in a patient with proven invasive aspergillosis. With the exception of treatment with the echinocandin, no other factors were found that might explain this clinical observation, which was supported by experiments done in vitro.

Assuntos

Antifúngicos/uso terapêutico; Antígenos de Fungos/sangue; Aspergilose/tratamento farmacológico; Aspergillus fumigatus/imunologia; Pneumopatias Fúngicas/tratamento farmacológico; Peptídeos Cíclicos/uso terapêutico; Adulto; Aspergilose/imunologia; Caspofungina; Equinocandinas; Proteínas Fúngicas/uso terapêutico; Transplante de Células-Tronco Hematopoéticas; Humanos; Hospedeiro Imunocomprometido; Imunossupressores/uso terapêutico; Lipopeptídeos; Pneumopatias Fúngicas/imunologia; Masculino; Síndromes Mielodisplásicas/terapia

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Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Aspergilose / Aspergillus fumigatus / Pneumopatias Fúngicas / Antifúngicos / Antígenos de Fungos Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2006 Tipo de documento: Article

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