Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
Bioorg Med Chem Lett
; 16(18): 4941-5, 2006 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-16806920
ABSTRACT
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Proteínas Tirosina Fosfatases
/
Ácido Aspártico
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article