Modulation of astrocyte proliferation by HIV-1: differential effects in productively infected, uninfected, and Nef-expressing cells.
J Neuroimmunol
; 178(1-2): 87-99, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16814871
ABSTRACT
Although quiescent in normal brain, reactive astrocytes can proliferate in various disorders. We examined the impact of HIV-1 on astrocyte proliferation in cultures exposed to VSVg env-pseudotyped HIV-1 which yields high levels of infection. HIV-1, while increasing the proliferation of uninfected (p24-) astrocytes, strongly inhibited proliferation of productively infected (p24+) cells. The cell cycle arrest was G1/S rather than G2/M, a type commonly attributed to Vpr. No clear role of Vpr or Nef could be identified. Adenovirus-mediated expression of Nef (a model of "restricted" infection) induced M-phase arrest of astrocytes. We speculate that HIV-1 is a significant modulator of astrocyte proliferation in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Receptores de HIV
/
Astrócitos
/
Proliferação de Células
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article